One thing I was trying to do are stronger and more natural looking facial features. For example, I went for stronger jaws and wider noses, but then also deselected a lot of the eye presets that look somewhat crooked or cartoon-like to me.

This mod disables make-up and accessories (incl. tattoos and hats) when randomizing a sim in CAS. As a bonus, from my understanding & testing, the same game mechanic is then also applied for any randomly generated townies in-game (not including NPC outfits).